Since many years, capsaicin plays a role in neuropathic pain treatment. It causes peripheral nervous system desensitivization via an interesting mechanism of action. Extracted from Capsicum’s seeds, capsaicin acts on a class of receptors, called TRPV receptors (Transient Receptor Potential Vanilloid), situated on the membrane of dendrites. Following the receptor activation due to capsaicin binding, a large amount of calcium ions enters the cell, and causes neuritis death. In this articles the authors explains a brief history of transdermal high concentration capsaicin patch usage, it’s clinical indications for neuropathic peripheral pain and their experience.
Keywords: Capsaicin, neuropathic pain
Also available in : Italiano